Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies From the Pharmaceutical Industry (English Edition)
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Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies From the Pharmaceutical Industry (2013)
EN NW FE EB DLISBN: 9783527658916 bzw. 3527658912, in Englisch, 401 Seiten, Wiley-VCH, neu, Erstausgabe, E-Book, elektronischer Download.
Lieferung aus: Vereinigte Staaten von Amerika, E-Book zum Download.
This one-stop reference source is the first on this new and exciting technology to focus on case studies of large-scale industrial applications, presenting the information and facts that are otherwise hard to find in the current literature. Authors from Pfizer, Merck, DSM, Novartis, Amgen, and Astra Zeneca, among others, use case studies to showcase project evolution from inception to early and late development, including commercial routes where applicable. Each case study details at least one transition metal-catalyzed cross-coupling step, with special emphasis on lessons learned from their implementation. The important issue of metal removal from the reaction mixtures to meet specifications and the different technologies available to accomplish this goal are also addressed. Finally, a small section covers novel technologies for cross-coupling with high future potential for applications on a large scale, such as metal removal on large scale, microwave and flow chemistry, as well as green chemistry. Of great interest to chemists working in the pharmaceutical, agrochemical and fine chemical industries, but also for every synthetic chemist working in academia., Kindle Edition, Ausgabe: 1, Format: Kindle eBook, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: eBooks, Publiziert: 2013-07-03, Freigegeben: 2013-07-03, Studio: Wiley-VCH, Verkaufsrang: 402796.
This one-stop reference source is the first on this new and exciting technology to focus on case studies of large-scale industrial applications, presenting the information and facts that are otherwise hard to find in the current literature. Authors from Pfizer, Merck, DSM, Novartis, Amgen, and Astra Zeneca, among others, use case studies to showcase project evolution from inception to early and late development, including commercial routes where applicable. Each case study details at least one transition metal-catalyzed cross-coupling step, with special emphasis on lessons learned from their implementation. The important issue of metal removal from the reaction mixtures to meet specifications and the different technologies available to accomplish this goal are also addressed. Finally, a small section covers novel technologies for cross-coupling with high future potential for applications on a large scale, such as metal removal on large scale, microwave and flow chemistry, as well as green chemistry. Of great interest to chemists working in the pharmaceutical, agrochemical and fine chemical industries, but also for every synthetic chemist working in academia., Kindle Edition, Ausgabe: 1, Format: Kindle eBook, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: eBooks, Publiziert: 2013-07-03, Freigegeben: 2013-07-03, Studio: Wiley-VCH, Verkaufsrang: 402796.
2
Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies From the Pharmaceutical Industry (2013)
EN NW FE EB DLISBN: 9783527658916 bzw. 3527658912, in Englisch, 401 Seiten, Wiley-VCH, neu, Erstausgabe, E-Book, elektronischer Download.
Lieferung aus: Deutschland, E-Book zum Download.
This one-stop reference source is the first on this new and exciting technology to focus on case studies of large-scale industrial applications, presenting the information and facts that are otherwise hard to find in the current literature. Authors from Pfizer, Merck, DSM, Novartis, Amgen, and Astra Zeneca, among others, use case studies to showcase project evolution from inception to early and late development, including commercial routes where applicable. Each case study details at least one transition metal-catalyzed cross-coupling step, with special emphasis on lessons learned from their implementation. The important issue of metal removal from the reaction mixtures to meet specifications and the different technologies available to accomplish this goal are also addressed. Finally, a small section covers novel technologies for cross-coupling with high future potential for applications on a large scale, such as metal removal on large scale, microwave and flow chemistry, as well as green chemistry. Of great interest to chemists working in the pharmaceutical, agrochemical and fine chemical industries, but also for every synthetic chemist working in academia., Kindle Edition, Ausgabe: 1, Format: Kindle eBook, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: eBooks, Publiziert: 2013-07-03, Freigegeben: 2013-07-03, Studio: Wiley-VCH.
This one-stop reference source is the first on this new and exciting technology to focus on case studies of large-scale industrial applications, presenting the information and facts that are otherwise hard to find in the current literature. Authors from Pfizer, Merck, DSM, Novartis, Amgen, and Astra Zeneca, among others, use case studies to showcase project evolution from inception to early and late development, including commercial routes where applicable. Each case study details at least one transition metal-catalyzed cross-coupling step, with special emphasis on lessons learned from their implementation. The important issue of metal removal from the reaction mixtures to meet specifications and the different technologies available to accomplish this goal are also addressed. Finally, a small section covers novel technologies for cross-coupling with high future potential for applications on a large scale, such as metal removal on large scale, microwave and flow chemistry, as well as green chemistry. Of great interest to chemists working in the pharmaceutical, agrochemical and fine chemical industries, but also for every synthetic chemist working in academia., Kindle Edition, Ausgabe: 1, Format: Kindle eBook, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: eBooks, Publiziert: 2013-07-03, Freigegeben: 2013-07-03, Studio: Wiley-VCH.
3
Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies From the Pharmaceutical Industry (English Edition) (2013)
EN NW FE EB DLISBN: 9783527658916 bzw. 3527658912, in Englisch, 401 Seiten, Wiley-VCH, neu, Erstausgabe, E-Book, elektronischer Download.
Lieferung aus: Deutschland, E-Book zum Download, Versandkostenfrei.
Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneering contributions to the field. The coming of age of this active area of research is showcased in this book through case studies in which process chemists from the pharmaceutical industry share their personal experiences developing their own transition metal-catalyzed couplings for the large-scale manufacture of active pharmaceutical ingredients. Authors from Pfizer, Merck, Boehringer-Ingelheim, Novartis, Amgen, GSK, AstraZeneca, and other companies describe the evolution of robust coupling processes from inception through early and late development, including commercial routes where applicable. This book covers a wide range of coupling transformations while capturing the lessons learned from each process. Every case study details the optimization of at least one transition metal-catalyzed coupling while elaborating on issues such as design of experiments, scalability and throughput, product purification, process safety, and waste management. The important issue of metal removal and the different technologies available to accomplish this goal are also addressed. Finally, a section covers novel technologies for cross-coupling with high potential for future applications on a large scale, such as microwave and flow chemistry as well as green cross-couplings performed in water. With Forewords by Stephen L. Buchwald, Massachusetts Institute of Technology, Trevor Laird, Editor of Organic Process Research and Development and Neal G. Anderson, Anderson's Process Solutions LLC. Kindle Ausgabe, Ausgabe: 1, Format: Kindle eBook, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: eBooks, Publiziert: 2013-07-03, Freigegeben: 2013-07-03, Studio: Wiley-VCH.
Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneering contributions to the field. The coming of age of this active area of research is showcased in this book through case studies in which process chemists from the pharmaceutical industry share their personal experiences developing their own transition metal-catalyzed couplings for the large-scale manufacture of active pharmaceutical ingredients. Authors from Pfizer, Merck, Boehringer-Ingelheim, Novartis, Amgen, GSK, AstraZeneca, and other companies describe the evolution of robust coupling processes from inception through early and late development, including commercial routes where applicable. This book covers a wide range of coupling transformations while capturing the lessons learned from each process. Every case study details the optimization of at least one transition metal-catalyzed coupling while elaborating on issues such as design of experiments, scalability and throughput, product purification, process safety, and waste management. The important issue of metal removal and the different technologies available to accomplish this goal are also addressed. Finally, a section covers novel technologies for cross-coupling with high potential for future applications on a large scale, such as microwave and flow chemistry as well as green cross-couplings performed in water. With Forewords by Stephen L. Buchwald, Massachusetts Institute of Technology, Trevor Laird, Editor of Organic Process Research and Development and Neal G. Anderson, Anderson's Process Solutions LLC. Kindle Ausgabe, Ausgabe: 1, Format: Kindle eBook, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: eBooks, Publiziert: 2013-07-03, Freigegeben: 2013-07-03, Studio: Wiley-VCH.
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