Chirality in Drug Research: From Synthesis to Pharmacology: 33 (Methods and Principles in Medicinal Chemistry)
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... In general, the book has been welledited and produced and contains a useful subject index. ChemM, ... In general, the book has been welledited and produced and contains a useful subject index. ChemMedChem ...As appropriately stressed throughout the book, th, Gebunden, Mathematik/Naturwissenschaften/Technik/Medizin.

Von Händler/Antiquariat, Book Deals [60506629], Lewiston, NY, U.S.A.
This Book is in Good Condition. Clean Copy With Light Amount of Wear. 100% Guaranteed. Summary: Preface. List of Contributors. Introduction. 1 Chiral Drugs from a Historical Point of View (Joseph Gal). 1.1 Introduction. 1.2 A Word About Words. 1.3 Old Chiral Drugs: Natural Remedies 3000BC-1900. 1.4 Recognition of Chirality in Drugs. 1.5 Enantioselectivity in Drug Action and Drug Metabolism: The Beginnings. 1.6 Drug Chirality in the 20th Century. References. Synthesis. 2 Stereoselective Synthesis of Drugs - An Industrial Perspective (Hans-Jurgen Federsel). 2.1 Introduction: Historical Overview. 2.2 Asymmetry from an Industrial Scale Perspective. 2.3 Stereoselective Processes in Drug Manufacture - Drivers and Blockers. 2.4 The Metal - Friend and Foe. 2.5 Ligand Development - At the Core of Catalytic Chemistry. 2.6 Asymmetric Reactions - A Rich Reservoir. 2.7 Retrospect and Prospect. References. 3 Aspects of Chirality in Natural Products Drug Discovery (Philipp Krastel, Frank Petersen, Silvio Roggo, Esther Schmitt, and Ansgar Schuffenhauer). 3.1 Introduction. 3.2 Stereochemical Aspects of Natural Products. 3.3 Mechanisms of Stereochemical Control in Natural Product Biosynthesis. 3.4 Biological Activity of Natural Products Related to Stereochemistry. References. 4 Biotransformation Methods for Preparing Chiral Drugs and Drug Intermediates (Michael Muller and Marcel Wubbolts). 4.1 Introduction. 4.2 Examples of Established Applications of Biocatalysts in the Synthesis of Pharmaceuticals. 4.3 Some Special Aspects of Biocatalysts, Recent Developments. 4.4 Conclusions and Outlook. References. Separations. 5 Resolution of Chiral Drugs and Drug Intermediates by Crystallisation (Kazuhiko Saigo). 5.1 Introduction. 5.2 Physical Enantioseparation - Preferential Crystallization. 5.3 Chemical Enantioseparation - Diastereomeric Salt Formation. 5.4 The Bridge Between Preferential Crystallization and Diastereomeric Salt Formation. 5.5 Process Research on the Enantioseparation of Racemates by Diastereomeric Salt Formation. 5.6 Examples of Enantioseparations in the Pharmaceutical Industry. References. 6 Isolation and Production of Optically Pure Drugs by Enantioselective Chromatography (Eric Francotte). 6.1 Introduction. 6.2 General Considerations Regarding the Preparation of Single Stereoisomers of Chiral Drugs. 6.3 Preparative Chiral Stationary Phases. 6.4 Strategies for Performing Enantioselective Separations. 6.5 Preparative Enantioselective Resolution of Chiral Drugs. 6.6 Conclusion. References. 7 Stereoselective Chromatographic Methods for Drug Analysis (Norbert M. Maier and Wolfgang Lindner). 7.1 Introduction. 7.2 The Role of Enantioselective Analysis in Drug Development. 7.3 Separation Techniques in Enantiomer Analysis. 7.4 Principle of Enantiomer Separation. 7.5 Molecular Requirements for Chiral Recognition. 7.6 Thermodynamic Principles of Enantiomer Separation. 7.7 Role of Mobile Phase in Enantiomer Separation. 7.8 Chiral Selectors and Chiral Stationary Phases Employed in Liquid Chromatographic Enantiomer Separation. 7.9 Conclusions. References. 8 Capillary Electrophoresis Coupled to Mass Spectrometry for Chiral Drugs Analysis (Serge Rudaz and Jean-Luc Veuthey). 8.1 Introduction. 8.2 Capillary Electrophoresis (CE). 8.3 CE-MS Coupling. 8.4 Chiral Separation Strategies. 8.5 Partial Filling. 8.6 Partial Filling - Counter Current Technique. 8.7 Chiral Micellar Electrokinetic Chromatography. 8.8 Quantitative Aspects in CE-MS.

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Von Händler/Antiquariat, Book Deals [60506629], Lewiston, NY, U.S.A.
Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: Preface. List of Contributors. Introduction. 1 Chiral Drugs from a Historical Point of View (Joseph Gal). 1.1 Introduction. 1.2 A Word About Words. 1.3 Old Chiral Drugs: Natural Remedies 3000BC-1900. 1.4 Recognition of Chirality in Drugs. 1.5 Enantioselectivity in Drug Action and Drug Metabolism: The Beginnings. 1.6 Drug Chirality in the 20th Century. References. Synthesis. 2 Stereoselective Synthesis of Drugs - An Industrial Perspective (Hans-Jurgen Federsel). 2.1 Introduction: Historical Overview. 2.2 Asymmetry from an Industrial Scale Perspective. 2.3 Stereoselective Processes in Drug Manufacture - Drivers and Blockers. 2.4 The Metal - Friend and Foe. 2.5 Ligand Development - At the Core of Catalytic Chemistry. 2.6 Asymmetric Reactions - A Rich Reservoir. 2.7 Retrospect and Prospect. References. 3 Aspects of Chirality in Natural Products Drug Discovery (Philipp Krastel, Frank Petersen, Silvio Roggo, Esther Schmitt, and Ansgar Schuffenhauer). 3.1 Introduction. 3.2 Stereochemical Aspects of Natural Products. 3.3 Mechanisms of Stereochemical Control in Natural Product Biosynthesis. 3.4 Biological Activity of Natural Products Related to Stereochemistry. References. 4 Biotransformation Methods for Preparing Chiral Drugs and Drug Intermediates (Michael Muller and Marcel Wubbolts). 4.1 Introduction. 4.2 Examples of Established Applications of Biocatalysts in the Synthesis of Pharmaceuticals. 4.3 Some Special Aspects of Biocatalysts, Recent Developments. 4.4 Conclusions and Outlook. References. Separations. 5 Resolution of Chiral Drugs and Drug Intermediates by Crystallisation (Kazuhiko Saigo). 5.1 Introduction. 5.2 Physical Enantioseparation - Preferential Crystallization. 5.3 Chemical Enantioseparation - Diastereomeric Salt Formation. 5.4 The Bridge Between Preferential Crystallization and Diastereomeric Salt Formation. 5.5 Process Research on the Enantioseparation of Racemates by Diastereomeric Salt Formation. 5.6 Examples of Enantioseparations in the Pharmaceutical Industry. References. 6 Isolation and Production of Optically Pure Drugs by Enantioselective Chromatography (Eric Francotte). 6.1 Introduction. 6.2 General Considerations Regarding the Preparation of Single Stereoisomers of Chiral Drugs. 6.3 Preparative Chiral Stationary Phases. 6.4 Strategies for Performing Enantioselective Separations. 6.5 Preparative Enantioselective Resolution of Chiral Drugs. 6.6 Conclusion. References. 7 Stereoselective Chromatographic Methods for Drug Analysis (Norbert M. Maier and Wolfgang Lindner). 7.1 Introduction. 7.2 The Role of Enantioselective Analysis in Drug Development. 7.3 Separation Techniques in Enantiomer Analysis. 7.4 Principle of Enantiomer Separation. 7.5 Molecular Requirements for Chiral Recognition. 7.6 Thermodynamic Principles of Enantiomer Separation. 7.7 Role of Mobile Phase in Enantiomer Separation. 7.8 Chiral Selectors and Chiral Stationary Phases Employed in Liquid Chromatographic Enantiomer Separation. 7.9 Conclusions. References. 8 Capillary Electrophoresis Coupled to Mass Spectrometry for Chiral Drugs Analysis (Serge Rudaz and Jean-Luc Veuthey). 8.1 Introduction. 8.2 Capillary Electrophoresis (CE). 8.3 CE-MS Coupling. 8.4 Chiral Separation Strategies. 8.5 Partial Filling. 8.6 Partial Filling - Counter Current Technique. 8.7 Chiral Micellar Electrokinetic Chromatography. 8.8 Quantitative Aspects in CE-MS.

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