Fragment-based Drug Discovery als von Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
7 Angebote vergleichen

Lieferung aus: Deutschland, Versandkostenfrei.
Fragment-based Drug Discovery: From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets. Englisch, Buch.

Lieferung aus: Kanada, Lagernd, zzgl. Versandkosten.
Books, Health and Well Being, Fragment-based Drug Discovery: Lessons and Outlook, From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

Lieferung aus: Deutschland, Lieferzeit: 11 Tage.
The secret of success in drug discovery written by the pioneers in the field with unrivaled experience in fragment-based methods.In this handbook, the first-hand knowledge imparted by the world's leading experts provides a comprehensive overview of current methods and applications of fragment-based discovery. The first part discusses basic considerations concerning when to use such methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel, and emerging techniques for fragment screening, including empirical as well as computational approaches, while also discussing such special cases as complex target systems and covalent inhibitors. The third and final part presents a number of successful real-world studies from recent and on-going drug discovery projects relating to a variety of target classes, from kinases and phosphatases to beta-secretase and epigenetic targets.With its discussion of future developments and potential novel applications, this will remain a valuable reference source for years to come.

Lieferung aus: Deutschland, 7 Werktage.
Daniel A. Erlanson is the co-founder and President of Carmot Therapeutics, Inc., which is developing, Daniel A. Erlanson is the co-founder and President of Carmot Therapeutics, Inc., which is developing fragment-based approaches to address unmet needs in drug di, Gebunden, Mathematik/Naturwissenschaften/Technik/Medizin.

Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, Versandkostenfrei.
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Lieferung aus: Vereinigte Staaten von Amerika, Lagernd, zzgl. Versandkosten.
Fragment-based-Drug-Discovery~~Daniel-A-Erlanson, Fragment-based Drug Discovery: Lessons and Outlook, Hardcover.

Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, 4-9 business days.