Metabolism of Drugs and Other Xenobiotics (English Edition)
12 Angebote vergleichen

Lieferung aus: Deutschland, Versandkostenfrei.
Metabolism of Drugs and Other Xenobiotics: InhaltsangabePart One Biochemistry and Molecular Genetics of Drug Metabolism 11 Drug-Metabolizing Enzymes &ndash An Overview 3 Pavel Anzenbacher and Eva Anzenbacherov&aacute 1.1 Introduction: Fate of a Drug in the Human Body 31.2 Classifi cation Systems of Drug-Metabolizing Enzymes According to Different Criteria 41.3 Overview of the Most Important Drug-Metabolizing Enzymes 6Acknowledgments 20References 202 Cytochromes P450 27 F. Peter Guengerich2.1 Introduction and Historical Perspective 272.2 Nomenclature and Gene Organization 292.3 Regulation 322.4 Polymorphisms 352.5 Protein Structure 372.6 Catalytic Mechanisms 402.7 What Determines P450 Catalytic Selectivity 452.8 Oxidative Stress and P450s 472.9 Relevance in Drug Metabolism and Clinical Medicine 48References 533 UDP-Glucuronosyltransferases 67 Christian P. Strassburg and Sandra Kalthoff3.1 Introduction 673.2 A Simple Phenotype: Unconjugated Nonhemolytic Hyperbilirubinemia and Glucuronidation 673.3 Organization of UGTs and the UGT1A Gene Locus 683.4 UGT1A Gene Nomenclature 703.5 Human UGT1A Gene Locus and Sequence Variability 713.6 Glucuronidation of Bilirubin 783.7 UGT1A1 Gene 793.8 Is There an Advantage or Risk Associated with UGT1A1 Variability 803.9 UGT1A1 Gene and Pharmacogenetic Protection 823.10 UGT1A1 Gene and Pharmacogenetic Risks 833.11 UGT1A1 Variability and Cancer Risk 863.12 UGT1A3 Gene 873.13 UGT1A7 Gene 883.14 Transcriptional Regulation of UGT1A Genes 953.15 Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Regulation of UGT1A Genes 953.16 Regulation by Hepatic Nuclear Factors 973.17 Regulation by the Farnesoid X Receptor 973.18 Regulation by Nuclear Factor Erythroid 2-Related Factor 2 983.19 Regulation by Splice Variants 983.20 Animal Models to Study UGT1A Genes 993.21 Outlook 100Acknowledgments 101References 1014 Sulfotransferases 117 Michael W. H. Coughtrie4.1 Introduction 1174.2 Background 118< Carboxylesterases 1656.2 Epoxide Hydrolases 1786.3 Paraoxonases 1836.4 Other Hydrolases 188References 1917 Transporting Systems 199 Anne T. Nies, Claudia Resch, and Tadashi Namisaki7.1 Introduction 1997.2 Classification of Drug Transporters and Transport Mechanisms 1997.3 Drug Transporters of the SLC Superfamily 2007.4 ABC Drug Transporters 2087.5 Drug Transporters and Disease 2087.6 Drug Transporters and Pharmacokinetics 2127.7 Role of Drug Transporters in Chemotherapy Resistance 2147.8 Pharmacogenomics of Drug Transporters: Implications for Clinical Drug Response 215Acknowledgments 215References 2168 Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes 223 Zdenek Dvorak8.1 Factors Affecting Drug-Metabolizing Cytochromes P450 2238.2 Transcriptional Regulation of CYP 2248.3 Regulation of Drug-Metabolizing CYPs 230Acknowledgments 238References 2389 Importance of Pharmacogenomics 259 Ulrich M. Zanger, Kathrin Klein, and Jessica Rieger9.1 Introduction 2599.2 Pharmacogenetic Polymorphisms 2609.3 Polygenic and Multifactorial Aspects of Drug Metabolism Phenotype 2709.4 Genomics Technologies and Approaches 2739.5 Conclusions 276References 276Part Two Metabolism of Drugs 28510 Introduction to Drug Metabolism 287 Ulrich M. Zanger10.1 Introduction 28710.2 Historical Aspects 28710.3 Diversity of Drug Metabolic Pathways 28810.4 Infl uence of Drug Metabolism on Pharmacological Activity 28910.5 Biotoxification 29010.6 Extrahepatic Drug Metabolism 29010.7 Factors Affecting Drug Metabolism Activity 29110.8 Conclusions 296References 29611 Central Nervous System Drugs 301 Pierre Baumann and Christoph Hiemke11.1 Introduction 30111.2 Antidepressants 30111.3 Antipsychotics 30611.4 Tranquillizers and Hypnotic Agents 30911.5 Psychostimulants 31111.6 Anticonvulsants and Mood Stabilizers 31111.7 Agents for Dementia and Cognitive Enhancers 31311.8 Antimigraine Drugs 31311.9 Other Drugs 31411.10 37013.6 Endocrine Therapy 37213.7 Histone Deacetylase Inhibitor (Vorinostat) 37313.8 Tyrosine Kinase Inhibitors 37313.9 Proteasome Inhibitor (Bortezomib) 374References 37414 Antimicrobial Agents 379 Chantal Csajka, Oscar Marchetti, Oriol Manuel, Laurent Decosterd, and Amalio Telenti14.1 Introduction 37914.2 Pharmacokinetics/Pharmacodynamics of the Main Families of Antimicrobial Agents 38014.3 Pharmacogenetics 39314.4 Conclusions 397Acknowledgments 398References 39815 Drugs against Acute and Chronic Pain 403 Andrew A. Somogyi and Janet K. Coller15.1 Introduction 40315.2 Acute Pain 40315.3 Chronic Pain 410References 42116 Drugs of Abuse (Including Designer Drugs) 429 Markus R. Meyer and Hans H. Maurer16.1 Introduction 42916.2 Classic Drugs of Abuse 43216.3 Designer Drugs of Abuse 435References 45017 Nicotine Metabolism and its Implications 465 Andy Z.X. Zhu and Rachel F. Tyndale17.1 Introduction 46517.2 Absorption and Distribution of Nicotine 46517.3 Excretion of Nicotine 46617.4 Metabolism of Nicotine 46817.5 Sources of Variation in Nicotine Metabolism 47117.6 Implications of Variation in Nicotine Metabolism and CYP2A6 Activity 48117.7 Conclusions 483Acknowledgments 483References 48418 Metabolism of Alcohol and its Consequences 493 Helmut K. Seitz and Sebastian Mueller18.1 Introduction 49318.2 Properties and Sources of Ethanol 49418.3 Ethanol Absorption and Elimination 49518.4 Ethanol Metabolism 497Acknowledgments 511References 511Part Three Metabolism of Natural Compounds 51719 Introduction and Overview 519 Michael Murray19.1 Introduction 51919.2 Terpenoids: A Structurally Complex Group of Natural Products 52219.3 Other Classes of Natural Products 53119.4 Summary and Conclusions 536Acknowledgments 536References 53620 Flavonoids 543 Petr Hodek20.1 Flavonoids &ndash Plant Phytochemicals 54320.2 Absorption and Me, Englisch, Ebook.

Lieferung aus: Russische Föderation, zzgl. Versandkosten.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Vereinigte Staaten von Amerika, Usually ships in 6 to 10 days.
Von Händler/Antiquariat, Amazon.com.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Deutschland, E-Book zum Download, Versandkostenfrei.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Deutschland, E-Book zum Download.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Vereinigte Staaten von Amerika, E-Book zum Download.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Deutschland, E-Book zum Download.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Vereinigte Staaten von Amerika, E-Book zum Download.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Deutschland, E-Book zum Download.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen

Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, Despatched same working day before 3pm.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen