Pharmacokinetic Optimization in Drug Research. Biological. Physicochemical. and Computational Strategies: Biological. Physicochemical and Computational Strategies
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Pharmacokinetic Optimization in Drug Research (2002)
DE HC NWISBN: 9783906390222 bzw. 3906390225, in Deutsch, Wiley-VCH, gebundenes Buch, neu.
Lieferung aus: Vereinigte Staaten von Amerika, Versandkostenfrei.
Von Händler/Antiquariat, Book Deals [60506629], Lewiston, NY, U.S.A.
Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: Preface (B. Testa) SETTING THE SCENE Pharmacokinetic Challenges in Lead Optimization (G. Gaviraghi, R.J. Barnaby and M. Pellegatti) Modelling in Preclinical and Clinical Drug Development (L.P. Balant and M. Gex-Fabry) MOLECULAR AND BIOLOGICAL BACKGROUND Structure of Liposomal Membranes in Relation to Permeation (O.G. Mouritsen, H.K. Andersen, J.S. Andersen, J. Davidsen, L.K. Nielsen and K. Jrgensen) Relations of Molecular Properties with Drug Disposition: The Cases of Gastrointestinal Absorption and Brain Penetration (H. van de Waterbeemd and D.A. Smith) Structure-Metabolism Relations, and the Challenge of redicting Biotransformation (B. Testa and G. Cruciani) Concepts in Prodrug Design to Overcome Pharmacokinetic Problems (B. Testa and J.M. Mayer) BIOLOGICAL STRATEGIES Methodologies in Cell Culture (H. Wunderli-Allenspach) Biological Models to Assess Drug Bioavailability (R.T. Borchardt) Biological Models to Study Blood-Brain Barrier Permeation (S.D. Krmer, N.J. Abbott and D.J. Begley) Biological Models to Study Skin Permeation (N. Sekkat and R.H. Guy) Biopharmaceutical Aspects of Nasal and Pulmonary Drug Delivery (P. Colombo, D. Cocconi, P. Santi, R. Bettini, G. Massimo, P.L. Catellani and C. Terzano) Significance of Plasma Protein Binding in Drug Research (S. Urien, J.-P. Tillement and J. Barr) High-Throughput ADE Screening (O. Kretz and A. Probst) In Vitro Models for Early Studies of Drug Metabolism (J.H. Lin and A.D. Rodrigues) Addressing Toxicological Issues in the Lead Optimization Phase of Drug Discovery and Evelopment (P. Bentley) PHYSICOCHEMICAL STRATEGIES Physicochemical Parameters as Tools in Drug Discovery and Lead Optimization (B. Faller and F. Wohnsland) Lipophilicity profiles: theory and measurement (J. Comer and K. Tam) High-Throughput Measurements of Solubility Profiles (A. Avdeef) Cyclic voltammetry as a new tool to study the partitioning and proton transport behaviour of ionized drugs (F. Reymond, G. Bouchard and H. Girault) Biolipid pKas and the Lipophilicity of Ampholytes and Ion Pairs (R.A. Scherrer) Recent Advances in Reversed-Phase-HPLC Techniques to Determine Lipophilicity (C. Yamagami) Liposome / Water Partitioning: Theory, Techniques and Applications (S.D. Krmer) Importance of the Mobile Phase in Immobilized Artificial Membrane Chromatography (K.L. Hauer and C. Pidgeon) High-Throughput Artificial Membrane Permeability Studies In Early Lead Discovery and Development (M. Kansy, H. Fischer, K. Kratzat, F. Senner, B. Wagner and I. Parrilla) NMR Spectroscopy for the Study of Drug-Phospholipid Interactions (R. Fruttero) COMPUTATIONAL STRATEGIES Virtual Screening of Molecular Properties: A Comparison of Log P Calculators (M.E. Duban, M.G. Bures, J. DeLazzer and Y.C. Martin) Quantitative Structure-Absorption Relationships (H.van de Waterbeemd) Hydrogen Bonding, the Last Mystery in Drug Design? (H. Kubinyi) Molecular Hydrogen-Bonding Potentials (MHBPs) in Structure-Permeation Relations (G. Caron, S. Rey, G. Ermondi, P. Crivori, P. Gaillard, P.-A. Carrupt and B. Testa) VolSurf and its Interest in Structure-Disposition Relationships (G. Cruciani, S. Clementi, P. Crivori, P.-A. Carrupt and B. Testa) Molecular Modeling Approaches to Predict Metabolism and Toxicity (A.M. ter Laak and N.P.E. Vermeulen) CONCLUSION Molecular Biology, Drug Design and Drug Delivery: Bringing It All Together (V.H.L. Lee, S.K. Wu and C. Chu) Pharmacokinetic lead optimization: fine art vs. blind technology (B. Testa).
Von Händler/Antiquariat, Book Deals [60506629], Lewiston, NY, U.S.A.
Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: Preface (B. Testa) SETTING THE SCENE Pharmacokinetic Challenges in Lead Optimization (G. Gaviraghi, R.J. Barnaby and M. Pellegatti) Modelling in Preclinical and Clinical Drug Development (L.P. Balant and M. Gex-Fabry) MOLECULAR AND BIOLOGICAL BACKGROUND Structure of Liposomal Membranes in Relation to Permeation (O.G. Mouritsen, H.K. Andersen, J.S. Andersen, J. Davidsen, L.K. Nielsen and K. Jrgensen) Relations of Molecular Properties with Drug Disposition: The Cases of Gastrointestinal Absorption and Brain Penetration (H. van de Waterbeemd and D.A. Smith) Structure-Metabolism Relations, and the Challenge of redicting Biotransformation (B. Testa and G. Cruciani) Concepts in Prodrug Design to Overcome Pharmacokinetic Problems (B. Testa and J.M. Mayer) BIOLOGICAL STRATEGIES Methodologies in Cell Culture (H. Wunderli-Allenspach) Biological Models to Assess Drug Bioavailability (R.T. Borchardt) Biological Models to Study Blood-Brain Barrier Permeation (S.D. Krmer, N.J. Abbott and D.J. Begley) Biological Models to Study Skin Permeation (N. Sekkat and R.H. Guy) Biopharmaceutical Aspects of Nasal and Pulmonary Drug Delivery (P. Colombo, D. Cocconi, P. Santi, R. Bettini, G. Massimo, P.L. Catellani and C. Terzano) Significance of Plasma Protein Binding in Drug Research (S. Urien, J.-P. Tillement and J. Barr) High-Throughput ADE Screening (O. Kretz and A. Probst) In Vitro Models for Early Studies of Drug Metabolism (J.H. Lin and A.D. Rodrigues) Addressing Toxicological Issues in the Lead Optimization Phase of Drug Discovery and Evelopment (P. Bentley) PHYSICOCHEMICAL STRATEGIES Physicochemical Parameters as Tools in Drug Discovery and Lead Optimization (B. Faller and F. Wohnsland) Lipophilicity profiles: theory and measurement (J. Comer and K. Tam) High-Throughput Measurements of Solubility Profiles (A. Avdeef) Cyclic voltammetry as a new tool to study the partitioning and proton transport behaviour of ionized drugs (F. Reymond, G. Bouchard and H. Girault) Biolipid pKas and the Lipophilicity of Ampholytes and Ion Pairs (R.A. Scherrer) Recent Advances in Reversed-Phase-HPLC Techniques to Determine Lipophilicity (C. Yamagami) Liposome / Water Partitioning: Theory, Techniques and Applications (S.D. Krmer) Importance of the Mobile Phase in Immobilized Artificial Membrane Chromatography (K.L. Hauer and C. Pidgeon) High-Throughput Artificial Membrane Permeability Studies In Early Lead Discovery and Development (M. Kansy, H. Fischer, K. Kratzat, F. Senner, B. Wagner and I. Parrilla) NMR Spectroscopy for the Study of Drug-Phospholipid Interactions (R. Fruttero) COMPUTATIONAL STRATEGIES Virtual Screening of Molecular Properties: A Comparison of Log P Calculators (M.E. Duban, M.G. Bures, J. DeLazzer and Y.C. Martin) Quantitative Structure-Absorption Relationships (H.van de Waterbeemd) Hydrogen Bonding, the Last Mystery in Drug Design? (H. Kubinyi) Molecular Hydrogen-Bonding Potentials (MHBPs) in Structure-Permeation Relations (G. Caron, S. Rey, G. Ermondi, P. Crivori, P. Gaillard, P.-A. Carrupt and B. Testa) VolSurf and its Interest in Structure-Disposition Relationships (G. Cruciani, S. Clementi, P. Crivori, P.-A. Carrupt and B. Testa) Molecular Modeling Approaches to Predict Metabolism and Toxicity (A.M. ter Laak and N.P.E. Vermeulen) CONCLUSION Molecular Biology, Drug Design and Drug Delivery: Bringing It All Together (V.H.L. Lee, S.K. Wu and C. Chu) Pharmacokinetic lead optimization: fine art vs. blind technology (B. Testa).
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Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, a.
DEISBN: 9783906390222 bzw. 3906390225, in Deutsch.
Von Händler/Antiquariat, Lux Libris [51657365], Dozwil, TG, Switzerland.
Praktisch wie neu, mit einer unpersönlichen Widmung und Autogramm des Autors Bernerd Testa im Vorsatz.
Praktisch wie neu, mit einer unpersönlichen Widmung und Autogramm des Autors Bernerd Testa im Vorsatz.
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Symbolbild
Pharmacokinetic Optimization in Drug Research
~EN USISBN: 9783906390222 bzw. 3906390225, vermutlich in Englisch, Wiley-VCH, gebraucht, guter Zustand.
Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, Versandkosten nach: DEU.
Von Händler/Antiquariat, Phatpocket Limited.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, Phatpocket Limited.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
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Pharmacokinetic Optimization in Drug Research. Biological, Physicochemical and Computational Strategies. (2001)
DE USISBN: 9783906390222 bzw. 3906390225, in Deutsch, Verlag Helvetica Chimica Acta / Wiley-VCH, gebraucht.
Antiquariat Axel Mehlig, [3406281].
(655 S.) mit CD-ROM Proceedings 25 cm, gebundene AusgabeFussschnitt angeschmutzt.
(655 S.) mit CD-ROM Proceedings 25 cm, gebundene AusgabeFussschnitt angeschmutzt.
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