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100%: Editor: Bernhard Lippert: Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug (ISBN: 9783906390420) 2006, Erstausgabe, in Englisch, Broschiert.Nur diese Ausgabe anzeigen…
88%: Bernhard Lippert (Editor): Cisplatin - Chemistry and Biochemistry of a Leading Anticancer Drug (ISBN: 9783906390208) 1999, Erstausgabe, in Englisch, Broschiert.Nur diese Ausgabe anzeigen…
Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug
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1
Symbolbild
Cisplatin (2006)
EN NW FEISBN: 9783906390420 bzw. 390639042X, in Englisch, 576 Seiten, Wiley-VCH, neu, Erstausgabe.
Lieferung aus: Vereinigte Staaten von Amerika, Usually ships in 1 to 2 months.
Von Händler/Antiquariat, Amazon.com.
30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter. , Printed Access Code, Ausgabe: 1, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: Book, Publiziert: 2006-11-09, Studio: Wiley-VCH.
Von Händler/Antiquariat, Amazon.com.
30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter. , Printed Access Code, Ausgabe: 1, Label: Wiley-VCH, Wiley-VCH, Produktgruppe: Book, Publiziert: 2006-11-09, Studio: Wiley-VCH.
2
Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug (1999)
EN HC NW FEISBN: 9783906390208 bzw. 3906390209, in Englisch, 576 Seiten, Wiley-VCH, gebundenes Buch, neu, Erstausgabe.
Ново от: $154.50 (2 Оферти)
Използван от: $136.57 (8 Оферти)
Покажи още 10 Оферти в Amazon.com
Lieferung aus: Vereinigte Staaten von Amerika, Usually ships in 1-2 business days.
Von Händler/Antiquariat, ClassicBooks-US.
Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Since Rosenberg's serendipitous discovery of its antitumor activity, cisplatin has become one of the greatest success stories of cancer chemotherapy. The biomedical applications of this inorganic compound have had an enormous impact on the development of coordination chemistry, and have served to underline the critical importance of basic research. This book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how cisplatin may trigger a cascade of cellular events that result ultimately in apoptosis. In Part 1, Rosenberg describes in a very personal manner the history of cisplatin from its accidental discovery to its establishment as a leading cancer drug. In Part 2 is described the current clinical status of platinum-derived antitumor agents. The biochemistry of cisplatin and current views of its mode of action comprise Part 3, while Part 4 focuses on the chemistry relevant to interactions of platinum(II) species with biomolecules. The examples compiled in Part 5 elucidate the impact of cisplatin on specific fields within inorganic chemistry, from the platinum blues' to platinum(III) compounds. The book concludes with Part 6, a description of several new developments in the field, e.g., orally active platinum drugs and the screening of combinatorial libraries of platinum compounds for antitumor activity. This volume provides all scientists, from coordination chemists to oncologists, with a unique resource detailing the state-of-the-art and future research perspectives, together with the fascinating story, of cisplatin. Hardcover, Издание: 1, Етикет: Wiley-VCH, Wiley-VCH, Продуктова група: Book, Публикувани: 1999-06-10, Студио: Wiley-VCH, Продажбата ранг: 11553895.
Von Händler/Antiquariat, ClassicBooks-US.
Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Since Rosenberg's serendipitous discovery of its antitumor activity, cisplatin has become one of the greatest success stories of cancer chemotherapy. The biomedical applications of this inorganic compound have had an enormous impact on the development of coordination chemistry, and have served to underline the critical importance of basic research. This book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how cisplatin may trigger a cascade of cellular events that result ultimately in apoptosis. In Part 1, Rosenberg describes in a very personal manner the history of cisplatin from its accidental discovery to its establishment as a leading cancer drug. In Part 2 is described the current clinical status of platinum-derived antitumor agents. The biochemistry of cisplatin and current views of its mode of action comprise Part 3, while Part 4 focuses on the chemistry relevant to interactions of platinum(II) species with biomolecules. The examples compiled in Part 5 elucidate the impact of cisplatin on specific fields within inorganic chemistry, from the platinum blues' to platinum(III) compounds. The book concludes with Part 6, a description of several new developments in the field, e.g., orally active platinum drugs and the screening of combinatorial libraries of platinum compounds for antitumor activity. This volume provides all scientists, from coordination chemists to oncologists, with a unique resource detailing the state-of-the-art and future research perspectives, together with the fascinating story, of cisplatin. Hardcover, Издание: 1, Етикет: Wiley-VCH, Wiley-VCH, Продуктова група: Book, Публикувани: 1999-06-10, Студио: Wiley-VCH, Продажбата ранг: 11553895.
3
Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug (1999)
EN HC US FEISBN: 9783906390208 bzw. 3906390209, in Englisch, 576 Seiten, Wiley-VCH, gebundenes Buch, gebraucht, Erstausgabe.
Ново от: $154.50 (2 Оферти)
Използван от: $136.57 (8 Оферти)
Покажи още 10 Оферти в Amazon.com
Lieferung aus: Vereinigte Staaten von Amerika, Usually ships in 1-2 business days.
Von Händler/Antiquariat, booksbyvee.
Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Since Rosenberg's serendipitous discovery of its antitumor activity, cisplatin has become one of the greatest success stories of cancer chemotherapy. The biomedical applications of this inorganic compound have had an enormous impact on the development of coordination chemistry, and have served to underline the critical importance of basic research. This book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how cisplatin may trigger a cascade of cellular events that result ultimately in apoptosis. In Part 1, Rosenberg describes in a very personal manner the history of cisplatin from its accidental discovery to its establishment as a leading cancer drug. In Part 2 is described the current clinical status of platinum-derived antitumor agents. The biochemistry of cisplatin and current views of its mode of action comprise Part 3, while Part 4 focuses on the chemistry relevant to interactions of platinum(II) species with biomolecules. The examples compiled in Part 5 elucidate the impact of cisplatin on specific fields within inorganic chemistry, from the platinum blues' to platinum(III) compounds. The book concludes with Part 6, a description of several new developments in the field, e.g., orally active platinum drugs and the screening of combinatorial libraries of platinum compounds for antitumor activity. This volume provides all scientists, from coordination chemists to oncologists, with a unique resource detailing the state-of-the-art and future research perspectives, together with the fascinating story, of cisplatin. Hardcover, Издание: 1, Етикет: Wiley-VCH, Wiley-VCH, Продуктова група: Book, Публикувани: 1999-06-10, Студио: Wiley-VCH, Продажбата ранг: 11553895.
Von Händler/Antiquariat, booksbyvee.
Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Since Rosenberg's serendipitous discovery of its antitumor activity, cisplatin has become one of the greatest success stories of cancer chemotherapy. The biomedical applications of this inorganic compound have had an enormous impact on the development of coordination chemistry, and have served to underline the critical importance of basic research. This book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how cisplatin may trigger a cascade of cellular events that result ultimately in apoptosis. In Part 1, Rosenberg describes in a very personal manner the history of cisplatin from its accidental discovery to its establishment as a leading cancer drug. In Part 2 is described the current clinical status of platinum-derived antitumor agents. The biochemistry of cisplatin and current views of its mode of action comprise Part 3, while Part 4 focuses on the chemistry relevant to interactions of platinum(II) species with biomolecules. The examples compiled in Part 5 elucidate the impact of cisplatin on specific fields within inorganic chemistry, from the platinum blues' to platinum(III) compounds. The book concludes with Part 6, a description of several new developments in the field, e.g., orally active platinum drugs and the screening of combinatorial libraries of platinum compounds for antitumor activity. This volume provides all scientists, from coordination chemists to oncologists, with a unique resource detailing the state-of-the-art and future research perspectives, together with the fascinating story, of cisplatin. Hardcover, Издание: 1, Етикет: Wiley-VCH, Wiley-VCH, Продуктова група: Book, Публикувани: 1999-06-10, Студио: Wiley-VCH, Продажбата ранг: 11553895.
4
Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug (1999)
EN HC US FEISBN: 9783906390208 bzw. 3906390209, in Englisch, 576 Seiten, Wiley VCH, gebundenes Buch, gebraucht, Erstausgabe.
Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, Usually dispatched within 1-2 business days, плюс доставката (ако доставят).
Von Händler/Antiquariat, Classique-uk.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, Classique-uk.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
5
Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug (1999)
DE HC US FEISBN: 9783906390208 bzw. 3906390209, in Deutsch, U.S.A.: Wiley-VCH, gebundenes Buch, gebraucht, Erstausgabe.
Von Händler/Antiquariat, suspiratio online bücherstube, [3126421].
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
6
Symbolbild
Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug
DE HC NWISBN: 9783906390420 bzw. 390639042X, in Deutsch, VCH PUBLISHER INC, gebundenes Buch, neu.
Lieferung aus: Vereinigte Staaten von Amerika, Nicht lagernd, zzgl. Versandkosten.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
8
Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug
DE HC NWISBN: 9783906390208 bzw. 3906390209, in Deutsch, Wiley, gebundenes Buch, neu.
Lieferung aus: Vereinigte Staaten von Amerika, На склад, плюс доставка.
Cisplatin~~Bernhard-Lippert, Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, Hardcover.
Cisplatin~~Bernhard-Lippert, Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, Hardcover.
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