The Clinical, Genetic, History and Management of Sickle cell anaemia
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Lieferung aus: Vereinigte Staaten von Amerika, Lagernd.
In 1910, sickle cell disease burst onto the Western medical scene as a strange or, as Herrick termed it, a new, unknown disease. Physicians were intrigued by the sickled appearance of the red cells in this disorder, and case reports and analytical papers detailing the clinical features of this disorder appeared to almost always involve people of colour. The disease then became known as a black disease. Not until 1949, however, was the molecular nature of sickle cell discovered. In 1958, Ingram discovered the genetic basis of the disease and demonstrated that the disease originated from the substitution of a valine for glutamic acid at the sixth amino acid position of the haemoglobin beta chain. This amino acid substitution, now known to be the result of a single point mutation of the haemoglobin gene, produces profound changes in the behaviour and conformation of the haemoglobin molecule in individuals affected by the disease. In 1927, Hahn and Gillespie had reported on the mechanism of sickle formation, observing that the sickle haemoglobin in its deoxygenated state assumed the characteristic shape, the sickle, that gives the disorder its name. Cells containing deoxygenated haemoglobin not only formed this rigid shape but also were dehydrated, had abnormal cell surface and distinct migratory characteristics, were sticky and prone to adhesion, and had abnormal rheological properties. Clinically, not only did patients with sickle cell disease experience repeated painful episodes (crises), but because of recurrent episodes of vaso-occlusion, they ultimately suffered chronic organ damage. Physicians noted a paucity of individuals who survived into their adult years. Sickle cell disease, one of the most common inherited diseases worldwide, is now understood to be a disorder of global importance and economic as well as clinical significance. Those affected by the disease live in areas of sub-Saharan Africa, the Middle East, India, the Caribbean, South and Central America, some countries along the Mediterranean Sea, as well as in the United States and Europe. This book covers the treatment and management of sickle cell anaemia as well as future recommendations.

Lieferung aus: Deutschland, Gewöhnlich versandfertig in 6 Tagen. Lieferung von Amazon, Versandkosten für geschätztes Warengewicht: 400g.
Von Händler/Antiquariat, Amazon.de.
Independently published, Taschenbuch, Publiziert: 2020-01-24T00:00:01Z, Produktgruppe: Book.

Lieferung aus: Niederlande, 3 - 4 weken.
bol.com.
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